Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.

European journal of biochemistry - 1 Dec 2002

Yang Hongmei, Lin Charles H, Ma Gang, Orr Melissa, Baffi Michael O, Wathelet Marc G

Abstract excerpt

Virus infection results in the activation of a set of cellular genes involved in host antiviral defense. IRF-3 has been identified as a critical transcription factor in this process. The activation mechanism of IRF-3 is not fully elucidated, yet it involves a conformational change triggered by the virus-dependent phosphorylation of its C-terminus. This conformational change leads to nuclear accumulation, DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to E1A-Associated p300 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Interferon Regulatory Factor-3

Share to Protein Biosynthesis

Share to Serine

Share to Threonine

Share to Transcriptional Activation

Source

Identifiers

PMID: 12473110
DOI: 10.1046/j.1432-1033.2002.03330.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.PMID 12473110Read ↗

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.Semantic proximity Read ↗

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3.Semantic proximity Read ↗

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3Semantic proximity Read ↗

Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation.Semantic proximity Read ↗

Crystal structure of IRF-3 in complex with CBP.Semantic proximity Read ↗

Kaposi's Sarcoma-associated Herpesvirus-encoded vIRF-3 Stimulates the Transcriptional Activity of Cellular IRF-3 and IRF-7Semantic proximity Read ↗

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.Semantic proximity Read ↗

Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex.Semantic proximity Read ↗

IFN Regulatory Factor 3 in Health and DiseaseSemantic proximity Read ↗

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.Semantic proximity Read ↗

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1Semantic proximity Read ↗

A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 proteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.