Article
IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo.
Oncogene - 20 Feb 2003
Kröger Andrea, Dallügge Andreas, Kirchhoff Sabine, Hauser Hansjörg
Abstract excerpt
The expression of the transcriptional activator and tumor suppressor IRF-1 induces multiple effects that counteract the growth of tumor cells in vitro and in vivo. These include the inhibition of cell proliferation, the secretion of interferon-beta (IFN-beta), the induction of apoptosis specifically in certain cell types and the induction of a strong T-cell response. Here, we show that apart from its...
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