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Article

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.

Molecular and cellular biology - 1 Feb 1999

Lin R, Heylbroeck C, Genin P, Pitha P M, Hiscott J

Abstract excerpt

Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and pathogenicity. Activation of the interferon regulatory factors (IRF) in turn is a critical mediator of cytokine gene transcription. Recent studies have focused on the 55-kDa IRF-3 gene product as a direct transcriptional regulator of type 1 interferon (IFN-alpha and IFN-beta) activation...

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Identifiers

PMID: 9891032
DOI: 10.1128/MCB.19.2.959
PMCID: PMC116027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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