Article
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.
Science (New York, N.Y.) - 12 Feb 1993
Harada H, Kitagawa M, Tanaka N, Yamamoto H, Harada K, Ishihara M, Taniguchi T
Abstract excerpt
Interferon regulatory factor-1 (IRF-1), a transcriptional activator, and IRF-2, its antagonistic repressor, have been identified as regulators of type I interferon and interferon-inducible genes. The IRF-1 gene is itself interferon-inducible and hence may be one of the target genes critical for i...
Topics
- 3T3 Cells
- Animals
- Blotting, Northern
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- DNA
- DNA-Binding Proteins
- Gene Expression
- Humans
- Immunosorbent Techniques
- Interferon Regulatory Factor-1