Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stat3 Activation Is Required for Cellular Transformation by v- <i>src</i>

1 May 1998

Abstract excerpt

Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Cytokine Signaling Pathways and Interactions
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9566875
DOI: 10.1128/mcb.18.5.2553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stat3 Activation Is Required for Cellular Transformation by v- <i>src</i>PMID 9566875Read ↗

Functional dissection of transformation by c‐Src and v‐SrcSemantic proximity Read ↗

Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) proteinSemantic proximity Read ↗

Overview of the STAT‑3 signaling pathway in cancer and the development of specific inhibitors (Review)Semantic proximity Read ↗

The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer TherapySemantic proximity Read ↗

Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells.Semantic proximity Read ↗

Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human TumorsSemantic proximity Read ↗

Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Human Telomerase Reverse Transcriptase (hTERT) Expression in Human Cancer and Primary CellsSemantic proximity Read ↗

Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3Semantic proximity Read ↗

Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.Semantic proximity Read ↗

SRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor CoactivatorSemantic proximity Read ↗

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.Semantic proximity Read ↗

EGFR dependent expression of STAT3 (but not STAT1) in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.