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Article

Direct repression of the human IRF-3 promoter by E2F1.

Immunogenetics - 1 Apr 2011

Xu Hua-Guo, Ren Wei, Zou Li, Wang Yi, Jin Rui, Zhou Guo-Ping

Abstract excerpt

Interferon regulatory factor 3 (IRF-3) plays an important role in virus and double-stranded RNA-mediated induction of type I interferon and RANTES, DNA damage signaling, tumor suppression, and virus-induced apoptosis. However, cis elements or trans factors responsible for regulating IRF-3 expression remain largely unknown. Here we report that the transcription factor E2F1 negatively regulates the basal...

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Identifiers

PMID: 21225257
DOI: 10.1007/s00251-010-0505-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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