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Article

LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses

23 May 2016

Abstract excerpt

Ongoing clinical trials are evaluating the benefits of systemic blockade of lymphocyte activation gene-3 (LAG-3) signals to improve immunity to tumors. Those studies are founded on the well-established inhibitory role of LAG-3 in regulating CD8(+) T cells during chronic virus infection and antitumor responses. However, the T cell response in LAG-3-deficient mice is similar in size and function to that in wild...

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Identifiers

PMID: 27206765
DOI: 10.4049/jimmunol.1401594

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