Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFN Regulatory Factor 3 in Health and Disease

1 Oct 2020

Abstract excerpt

Immunity to viruses requires an array of critical cellular proteins that include IFN regulatory factor 3 (IRF3). Consequently, most viruses that infect vertebrates encode proteins that interfere with IRF3 activation. This review describes the cellular pathways linked to IRF3 activation and where those pathways are targeted by human viral pathogens. Moreover, key regulatory pathways that control IRF3 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33020188
DOI: 10.4049/jimmunol.2000462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFN Regulatory Factor 3 in Health and DiseasePMID 33020188Read ↗

The emerging roles of IFIT3 in antiviral innate immunity and cellular biologySemantic proximity Read ↗

Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 ExpressionSemantic proximity Read ↗

Regulating IRFs in IFN Driven DiseaseSemantic proximity Read ↗

Beyond Good and Evil: Molecular Mechanisms of Type I and III IFN FunctionsSemantic proximity Read ↗

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene InductionSemantic proximity Read ↗

Interferon regulatory factor family of transcription factors and regulation of oncogenesis.Semantic proximity Read ↗

eIF4A3 Promotes RNA Viruses’ Replication by Inhibiting Innate Immune ResponsesSemantic proximity Read ↗

Interferon-Stimulated Genes: What Do They All Do?Semantic proximity Read ↗

Interferon Regulatory Factor 9 Structure and RegulationSemantic proximity Read ↗

Interferon regulatory factor 1 inactivation in human cancerSemantic proximity Read ↗

IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammationSemantic proximity Read ↗

[Review] The Landscape of Interferons in Health and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.