Article
Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 1999
Xing E P, Nie Y, Song Y, Yang G Y, Cai Y C, Wang L D, Yang C S
Abstract excerpt
The 9p21 gene cluster, harboring growth suppressive genes p14ARF, p15INK4b, and p16INK4a, is one of the major aberration hotspots in human cancers. It was shown that p14ARF and p16INK4a play active roles in the p53 and Rb tumor suppressive pathways, respectively, and p15INK4b is a mediator of the extracellular growth inhibition signals. To elucidate specific targets and aberrations affecting this subchromosomal...
Topics
- Carcinoma, Squamous Cell
- Cell Cycle Proteins
- Chromosomes, Human, Pair 9
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p15
- DNA Methylation
- Esophageal Neoplasms
- Gene Deletion
- Genes, Tumor Suppressor
- Genes, p16
- Helminth Proteins
- Humans