Article
5' cytosine-phospho-guanine island methylation is responsible for p14ARF inactivation and inversely correlates with p53 overexpression in resected non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2004
Hsu Han-Shui, Wang Yu-Chien, Tseng Ruo-Chia, Chang Jer-Wei, Chen Jung-Ta, Shih Chuen-Ming, Chen Chih-Yi, Wang Yi-Ching
Abstract excerpt
PURPOSE AND EXPERIMENTAL DESIGN: The molecular mechanisms by which the p14ARF gene is altered in non-small cell lung cancer (NSCLC) are complex and unclear. Using genetic and epigenetic analyses, we examined various molecular alterations including the loss of protein and mRNA expression, and 5'CpG hypermethylation, allelic imbalance, and mutation of the p14ARF gene in a series of 102 NSCLC samples, in parallel...
Topics
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
- Chromosomes, Human, Pair 9
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Methylation
- Female
- Gene Deletion