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Article

Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer.

International journal of cancer - 15 Mar 2006

Kraunz Kim S, Nelson Heather H, Lemos Miriam, Godleski John J, Wiencke John K, Kelsey Karl T

Abstract excerpt

Inactivation of p16(INK4a) in the Rb pathway is among the most common somatic alterations observed in nonsmall cell lung cancers (NSCLCs). While epigenetic inactivation of the p16(INK4a) gene promoter has been shown to be associated with increased tobacco carcinogen exposure, little investigation of any similar association of homozygous deletion or mutation of p16(INK4a) and tobacco use has been completed. In 177...

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Source

Identifiers

PMID: 16184554
DOI: 10.1002/ijc.21522

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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