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Article

Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas.

Clinical lung cancer - 1 Mar 2014

Cortot Alexis B, Younes Mohamad, Martel-Planche Ghislaine, Guibert Benoit, Isaac Sylvie, Souquet Pierre-Jean, Commo Frédéric, Girard Philippe, Fouret Pierre, Brambilla Elisabeth, Hainaut Pierre, Soria Jean-Charles

Abstract excerpt

BACKGROUND: In lung adenocarcinoma, inactivation of the tumor suppressor p53 may abrogate a safeguard mechanism preventing the development of tumors with activating mutations in EGFR or KRAS. To assess this hypothesis, we analyzed TP53 mutations and downregulation of p14(arf), a negative regulator of p53 activated by oncogenic signals, in a retrospective series of 96 patients with primary adenocarcinoma of the...

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Source

Identifiers

PMID: 24169260
DOI: 10.1016/j.cllc.2013.08.003

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas.PMID 24169260Read ↗

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