Article
CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2013
Tam Kit W, Zhang Wei, Soh Junichi, Stastny Victor, Chen Min, Sun Han, Thu Kelsie, Rios Jonathan J, Yang Chenchen, Marconett Crystal N, Selamat Suhaida A, Laird-Offringa Ite A, Taguchi Ayumu, Hanash Samir, Shames David, Ma Xiaotu, Zhang Michael Q, Lam Wan L, Gazdar Adi
Abstract excerpt
INTRODUCTION: CDKN2A (p16) inactivation is common in lung cancer and occurs via homozygous deletions, methylation of promoter region, or point mutations. Although p16 promoter methylation has been linked to KRAS mutation and smoking, the associations between p16 inactivation mechanisms and other common genetic mutations and smoking status are still controversial or unknown. METHODS: We determined all three p16...
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