Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway.

Oncogene - 21 Feb 2013

Ozenne P, Dayde D, Brambilla E, Eymin B, Gazzeri S

Abstract excerpt

Epidermal growth factor receptor (EGFR) stimulates proliferative and survival signals. Activating mutations of EGFR are involved in the aetiology and maintenance of the malignant phenotype of lung tumours. We previously described the frequent association of these mutations with the decreased expression of the p14(ARF) tumour suppressor, another common feature of lung cancer. Based on these data, we postulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Growth Processes

Share to Down-Regulation

Share to ErbB Receptors

Share to Proto-Oncogene Proteins c-bcl-2

Share to STAT3 Transcription Factor

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 22450744
DOI: 10.1038/onc.2012.107

Genes

EGFR
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway.PMID 22450744Read ↗

Antitumor impact of p14ARF on gefitinib-resistant non-small cell lung cancers.Semantic proximity Read ↗

Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas.Semantic proximity Read ↗

Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.Semantic proximity Read ↗

Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.Semantic proximity Read ↗

Non-Canonical Functions of the ARF Tumor Suppressor in Development and TumorigenesisSemantic proximity Read ↗

ARF inhibits the growth and malignant progression of non-small-cell lung carcinoma.Semantic proximity Read ↗

SCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma.Semantic proximity Read ↗

Mutation of the Conserved Threonine 8 within the Human ARF Tumour Suppressor Protein Regulates Autophagy.Semantic proximity Read ↗

MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.Semantic proximity Read ↗

Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.Semantic proximity Read ↗

ARLTS1 - a novel tumor suppressor gene.Semantic proximity Read ↗

Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.