Article
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
Cancer research - 15 Jun 2007
Mounawar Mounia, Mukeria Anush, Le Calvez Florence, Hung Rayjean J, Renard Helene, Cortot Alexis, Bollart Claire, Zaridze David, Brennan Paul, Boffetta Paolo, Brambilla Elisabeth, Hainaut Pierre
Abstract excerpt
Mutations in the tyrosine kinase domain of the epidermal growth factor receptor EGFR are common in non-small cell lung cancer (NSCLC) of never smokers, whereas HER2 mutations are rare. We have analyzed EGFR and HER2 mutations and the expression of the two products of the CDKN2A gene (p14(arf) and p16(INK4a)) in 116 NSCLC that have been previously analyzed for TP53 and KRAS mutations in relation to smoking history...
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