Article
Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2001
Geradts J, Wilentz R E, Roberts H
Abstract excerpt
The INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16(INK4a) and p14(ARF). Although the former is one of the most common targets for inactivation in human neoplasia, the frequency of p14(ARF) abrogation is not established. We have developed an immunohistochemical assay that allows the evaluation of p14(ARF) expression in formalin-fixed, paraffin-embedded tissues, using commercially...
Topics
- Adenocarcinoma
- DNA, Neoplasm
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Mutation
- Neoplasms
- Pancreatic Neoplasms
- Tumor Cells, Cultured