Article
The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit.
Molecular biology of the cell - 1 May 2008
Demmel Lars, Gravert Maike, Ercan Ebru, Habermann Bianca, Müller-Reichert Thomas, Kukhtina Viktoria, Haucke Volker, Baust Thorsten, Sohrmann Marc, Kalaidzidis Yannis, Klose Christian, Beck Mike, Peter Matthias, Walch-Solimena Christiane
Abstract excerpt
Phosphatidylinositol 4-phosphate (PI(4)P) is a key regulator of membrane transport required for the formation of transport carriers from the trans-Golgi network (TGN). The molecular mechanisms of PI(4)P signaling in this process are still poorly understood. In a search for PI(4)P effector molecules, we performed a screen for synthetic lethals in a background of reduced PI(4)P and found the gene GGA2. Our analysis...
Topics
- 1-Phosphatidylinositol 4-Kinase
- ADP-Ribosylation Factors
- Adaptor Proteins, Vesicular Transport
- Amino Acid Sequence
- Clathrin
- Genome, Fungal
- Golgi Apparatus
- Kinetics
- Models, Molecular