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Article

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.

The Journal of cell biology - 3 Apr 2000

Dell'Angelica E C, Puertollano R, Mullins C, Aguilar R C, Vargas J D, Hartnell L M, Bonifacino J S

Abstract excerpt

Formation of intracellular transport intermediates and selection of cargo molecules are mediated by protein coats associated with the cytosolic face of membranes. Here, we describe a novel family of ubiquitous coat proteins termed GGAs, which includes three members in humans and two in yeast. GGAs have a modular structure consisting of a VHS domain, a region of homology termed GAT, a linker segment, and a region...

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Source

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Identifiers

PMID: 10747089
DOI: 10.1083/jcb.149.1.81
PMCID: PMC2175099

Genes

ARF1
GGA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.PMID 10747089Read ↗

Multiple phosphorylation events regulate the subcellular localization of GGA1.Semantic proximity Read ↗

A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome.Semantic proximity Read ↗

Yeast Gga coat proteins function with clathrin in Golgi to endosome transport.Semantic proximity Read ↗

ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization.Semantic proximity Read ↗

Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.Semantic proximity Read ↗

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network.Semantic proximity Read ↗

COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.Semantic proximity Read ↗

GARP Complex in Golgi Physiology.Semantic proximity Read ↗

A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer.Semantic proximity Read ↗

GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination.Semantic proximity Read ↗

GGA function is required for maturation of neuroendocrine secretory granules.Semantic proximity Read ↗

Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat.Semantic proximity Read ↗

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