Article
Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.
Developmental cell - 1 Sept 2003
Nie Zhongzhen, Boehm Markus, Boja Emily S, Vass William C, Bonifacino Juan S, Fales Henry M, Randazzo Paul A
Abstract excerpt
Arf1 regulates membrane trafficking at several membrane sites by interacting with at least seven different vesicle coat proteins. Here, we test the hypothesis that Arf1-dependent coats are independently regulated by specific interaction with Arf GAPs. We find that the Arf GAP AGAP1 directly associates with and colocalizes with AP-3, a coat protein complex involved in trafficking in the endosomal-lysosomal system....
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