Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.

Abstract excerpt

Extensive cell-to-cell variation exists even among putatively identical cells, and there is great interest in understanding how the properties of transcription relate to this heterogeneity. Differential expression from the two gene copies in diploid cells could potentially contribute, yet our ability to measure from which gene copy individual RNAs originated remains limited, particularly in the context of...

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