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Article

Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6.

PLoS genetics - 1 Apr 2013

Donley Nathan, Stoffregen Eric P, Smith Leslie, Montagna Christina, Thayer Mathew J

Abstract excerpt

Mammalian chromosomes initiate DNA replication at multiple sites along their length during each S phase following a temporal replication program. The majority of genes on homologous chromosomes replicate synchronously. However, mono-allelically expressed genes such as imprinted genes, allelically excluded genes, and genes on female X chromosomes replicate asynchronously. We have identified a cis-acting locus on...

Topics

Alleles
Animals
Cell Line
Chromosomal Instability
Chromosomes, Human, Pair 6
DNA Replication
Female
Fibroblasts
Humans
In Situ Hybridization, Fluorescence
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitosis

RNA, Long Noncoding

X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 23593023
DOI: 10.1371/journal.pgen.1003423
PMCID: PMC3617217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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