Asynchronous replication of allelic loci in Down syndrome.

doi:10.1038/sj.ejhg.5200199

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Article

Asynchronous replication of allelic loci in Down syndrome.

European journal of human genetics : EJHG - 1 Jan 2000

Amiel A, Avivi L, Gaber E, Fejgin M D

Abstract excerpt

We have used FISH to determine the level of synchronisation in replication timing of four pairs of alleles, unrelated to chromosome 21 (p53, HER2, RB1, and c-myc), in foetal (amniotic fluid) cell samples of Down syndrome and in normal foetuses. All samples derived from the Down syndrome subjects...

Topics

Alleles
Cells, Cultured
DNA Replication
Down Syndrome
Humans
In Situ Hybridization, Fluorescence
Proto-Oncogene Proteins c-myc
Receptor, ErbB-2
Retinoblastoma Protein
Tumor Suppressor Protein p53

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