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Article

Asynchronous replication of allelic loci in Down syndrome.

European journal of human genetics : EJHG - 1 Jan 2000

Amiel A, Avivi L, Gaber E, Fejgin M D

Abstract excerpt

We have used FISH to determine the level of synchronisation in replication timing of four pairs of alleles, unrelated to chromosome 21 (p53, HER2, RB1, and c-myc), in foetal (amniotic fluid) cell samples of Down syndrome and in normal foetuses. All samples derived from the Down syndrome subjects showed large temporal differences in replication timing, in contrast to the high level of synchrony shown in all...

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Identifiers

PMID: 9781044
DOI: 10.1038/sj.ejhg.5200199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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