Article
Negative regulation of PrfA, the key activator of Listeria monocytogenes virulence gene expression, is dispensable for bacterial pathogenesis.
Microbiology (Reading, England) - 1 Jan 2003
Greene Sonya L, Freitag Nancy E
Abstract excerpt
Listeria monocytogenes is a facultative intracellular bacterial pathogen that regulates the expression of virulence-associated gene products in response to specific host cell compartment environments. The PrfA protein of L. monocytogenes functions as a key regulatory factor required for the differential expression of bacterial virulence gene products within infected host cells. PrfA both positively and negatively...
Topics
- Animals
- Bacterial Proteins
- Base Sequence
- Cells, Cultured
- Gene Expression Regulation, Bacterial
- Humans
- Lethal Dose 50
- Listeria monocytogenes
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data