A novel mutation within the central Listeria monocytogenes regulator PrfA that results in constitutive expression of virulence gene products.

Abstract excerpt

The PrfA protein of Listeria monocytogenes functions as a key regulatory factor for the coordinated expression of many virulence genes during bacterial infection of host cells. PrfA activity is controlled by multiple regulatory mechanisms, including an apparent requirement for either the presence of a cofactor or some form of posttranslational modification that regulates the activation of PrfA. In this study, we...

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