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Article

Constitutive activation of PrfA tilts the balance of Listeria monocytogenes fitness towards life within the host versus environmental survival.

PloS one - 7 Dec 2010

Bruno Joseph C, Freitag Nancy E

Abstract excerpt

PrfA is a key regulator of Listeria monocytogenes pathogenesis and induces the expression of multiple virulence factors within the infected host. PrfA is post-translationally regulated such that the protein becomes activated upon bacterial entry into the cell cytosol. The signal that triggers PrfA activation remains unknown, however mutations have been identified (prfA* mutations) that lock the protein into a...

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PMID: 21151923
DOI: 10.1371/journal.pone.0015138
PMCID: PMC2998416

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