Article
Constitutive activation of PrfA tilts the balance of Listeria monocytogenes fitness towards life within the host versus environmental survival.
PloS one - 7 Dec 2010
Bruno Joseph C, Freitag Nancy E
Abstract excerpt
PrfA is a key regulator of Listeria monocytogenes pathogenesis and induces the expression of multiple virulence factors within the infected host. PrfA is post-translationally regulated such that the protein becomes activated upon bacterial entry into the cell cytosol. The signal that triggers PrfA activation remains unknown, however mutations have been identified (prfA* mutations) that lock the protein into a...
Topics
- Alleles
- Animals
- Bacterial Proteins
- Bacteriophages
- Carbon
- Cytosol
- Glucose
- Glycerol
- Listeria monocytogenes
- Mice
- Mice, Inbred C57BL
- Mutation
- Peptide Termination Factors
- Protein Processing, Post-Translational
- Sigma Factor
- Stem Cells