Article
Functional impact of mutational activation on the Listeria monocytogenes central virulence regulator PrfA.
Microbiology (Reading, England) - 1 Nov 2008
Miner Maurine D, Port Gary C, Freitag Nancy E
Abstract excerpt
The transcriptional activator PrfA is required for the expression of virulence factors necessary for Listeria monocytogenes pathogenesis. PrfA is believed to become activated following L. monocytogenes entry into the cytosol of infected host cells, resulting in the induction of target genes whose products are required for bacterial intracellular growth and cell-to-cell spread. Several mutations have been...
Topics
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Humans
- Listeria monocytogenes
- Listeriosis
- Models, Molecular
- Mutation
- Peptide Termination Factors
- Promoter Regions, Genetic
- Protein Binding
- Trans-Activators
- Transcription, Genetic
- Virulence Factors