Identification and characterization of a novel PrfA-regulated gene in Listeria monocytogenes whose product, IrpA, is highly homologous to internalin proteins, which contain leucine-rich repeats.

doi:10.1128/iai.65.1.101-109.1997

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Article

Identification and characterization of a novel PrfA-regulated gene in Listeria monocytogenes whose product, IrpA, is highly homologous to internalin proteins, which contain leucine-rich repeats.

Infection and immunity - 1 Jan 1997

Domann E, Zechel S, Lingnau A, Hain T, Darji A, Nichterlein T, Wehland J, Chakraborty T

Abstract excerpt

The expression of all virulence factors in Listeria monocytogenes characterized to date is controlled by the virulence regulator protein, PrfA. To identify further PrfA-regulated proteins, we examined supernatants of L. monocytogenes EGD harboring additional copies of the PrfA regulator for the p...

Topics

Amino Acid Sequence
Animals
Bacterial Proteins
Base Sequence
Caco-2 Cells
Cloning, Molecular
Epithelium
Escherichia coli
Female
Gene Expression Regulation, Bacterial
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Listeria monocytogenes

Liver

Mice

Mice, Inbred BALB C

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8975898
DOI: 10.1128/iai.65.1.101-109.1997
PMCID: PMC174562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8975898-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification and characterization of a novel PrfA-regulated gene in Listeria monocytogenes whose product, IrpA, is highly homologous to internalin proteins, which contain leucine-rich repeats.PMID 8975898Read ↗

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The gene cluster inlC2DE of Listeria monocytogenes contains additional new internalin genes and is important for virulence in mice.Semantic proximity Read ↗

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