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Article

Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread.

Infection and immunity - 1 Jun 1993

Freitag N E, Rong L, Portnoy D A

Abstract excerpt

The prfA gene product is a transcriptional activator of Listeria monocytogenes determinants of pathogenicity. In this study, we provide direct evidence that the PrfA protein is a site-specific DNA-binding protein. Additionally, we describe the characterization of two classes of L. monocytogenes mutants which contain transposon insertions either in the prfA structural gene (exemplified by strain DP-L1075) or...

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Identifiers

PMID: 8388865
DOI: 10.1128/iai.61.6.2537-2544.1993
PMCID: PMC280881

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