Article
Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells.
The Journal of biological chemistry - 18 Apr 2003
Duchesne Cathia, Charland Stephanie, Asselin Claude, Nahmias Clara, Rivard Nathalie
Abstract excerpt
Protein-tyrosine phosphatase SHP-1 is expressed at high levels in hematopoietic cells and at moderate levels in many other cell types including epithelial cells. Although SHP-1 has been shown to be a negative regulator of multiple signaling pathways in hematopoietic cells, very little is known about the biological role of SHP-1 in epithelial cells. In order to elucidate the mechanism(s) responsible for the loss...
Topics
- Animals
- Binding Sites
- Blotting, Western
- Caco-2 Cells
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Nucleus
- Cyclin D1
- Cytoskeletal Proteins
- Epithelial Cells