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Article

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells.

Nature communications - 30 Oct 2014

Viant Charlotte, Fenis Aurore, Chicanne Gaëtan, Payrastre Bernard, Ugolini Sophie, Vivier Eric

Abstract excerpt

Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here that the protein tyrosine phosphatase SHP-1 is essential for the inhibitory function of NK cell...

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Share to Cells, Cultured
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Source

Identifiers

PMID: 25355530
DOI: 10.1038/ncomms6108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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