Article
Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal growth factor- and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells.
The Journal of biological chemistry - 12 Sept 1997
You M, Zhao Z
Abstract excerpt
SHP-1 (also known as PTP1C, SHPTP-1, SHP, and HCP) is an SH2 domain-containing protein-tyrosine phosphatase. We have stably overexpressed the native form and a catalytically inactive cysteine to serine mutant of the enzyme, SHP-1-(Cys --> Ser), in human cervical carcinoma HeLa cells. Following st...
Topics
- Enzyme Activation
- Epidermal Growth Factor
- ErbB Receptors
- HeLa Cells
- Humans
- Interferon-gamma
- Intracellular Signaling Peptides and Proteins
- MAP Kinase Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Phosphorylation