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Article

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.

Blood - 15 Feb 2001

Qu C K, Nguyen S, Chen J, Feng G S

Abstract excerpt

Shp-1 and Shp-2 are cytoplasmic phosphotyrosine phosphatases with similar structures. Mice deficient in Shp-2 die at midgestation with defects in mesodermal patterning, and a hypomorphic mutation at the Shp-1 locus results in the moth-eaten viable (me(v)) phenotype. Previously, a critical role of Shp-2 in mediating erythroid/myeloid cell development was demonstrated. By using the RAG-2-deficient blastocyst...

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Identifiers

PMID: 11159516
DOI: 10.1182/blood.v97.4.911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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