Molecular mechanisms underlying SHP‐1 gene expression

doi:10.1046/j.1432-1033.2002.02986.x

Article

Molecular mechanisms underlying SHP‐1 gene expression

1 Jun 2002

Abstract excerpt

SHP-1, a protein-tyrosine phosphatase with two src-homology 2 domains, is expressed predominantly in hematopoietic and epithelial cells and has been implicated in numerous signaling pathways as a negative regulator. Two promoters direct the expression of human and murine SHP-1, and two types of transcripts (I) and (II) SHP-1, are initiated from each of these promoters. The cDNA sequences of (I)SHP-1 and (II)SHP-1...

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