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Article

SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein.

Cellular signalling - 1 Jan 2011

Simoneau Mélanie, Coulombe Geneviève, Vandal Guillaume, Vézina Anne, Rivard Nathalie

Abstract excerpt

β-catenin plays a dual role both as a key effector in the regulation of adherens junctions and as a transcriptional coactivator. Tyrosine phosphorylation of β-catenin is implicated as a means for its release from E-cadherin complexes and correlates with enhanced transcriptional activity. However, it remains unclear whether or not tyrosine phosphorylated β-catenin degrades slower or faster than its...

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Source

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PMID: 20840866
DOI: 10.1016/j.cellsig.2010.09.011

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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