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Article

Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium.

PloS one - 1 Jan 2014

Yamashita Hironori, Kotani Takenori, Park Jung-Ha, Murata Yoji, Okazawa Hideki, Ohnishi Hiroshi, Ku Yonson, Matozaki Takashi

Abstract excerpt

Protein tyrosine phosphorylation is thought to be important for regulation of the proliferation, differentiation, and rapid turnover of intestinal epithelial cells (IECs). The role of protein tyrosine phosphatases in such homeostatic regulation of IECs has remained largely unknown, however. Src homology 2-containing protein tyrosine phosphatase (Shp2) is a ubiquitously expressed cytoplasmic protein tyrosine...

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Identifiers

PMID: 24675817
DOI: 10.1371/journal.pone.0092904
PMCID: PMC3968040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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