Article
Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
European journal of immunology - 1 Aug 1999
Brockdorff J, Williams S, Couture C, Mustelin T
Abstract excerpt
Studies with motheaten mice, which lack the SHP1 protein tyrosine phosphatase, indicate that this enzyme plays an important negative role in T cell antigen receptor (TCR) signaling. The physiological substrates for SHP1 in T lymphocytes, however, have remained unclear or controversial. To define these targets for SHP1 we have compared the effects of constitutively active and inactive mutants of SHP1 on TCR...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- DNA-Binding Proteins
- Enzyme Activation
- Enzyme Precursors
- Humans
- Intracellular Signaling Peptides and Proteins
- Jurkat Cells
- Mice
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins
- Phosphorylation