Article
A human brain tumor-derived PDGFR-alpha deletion mutant is transforming.
Oncogene - 6 Feb 2003
Clarke I D, Dirks P B
Abstract excerpt
Aberrant receptor tyrosine kinase signaling plays an important role in the molecular pathogenesis of brain tumors. We have been studying a previously identified human glioblastoma-derived PDGFR-alpha mutant that has an in-frame deletion in the extracellular domain, causing loss of exons 8 and 9 (PDGFR-alpha(delta8,9)). In the primary tumor, this deletion mutant receptor was shown to be amplified and...
Topics
- Animals
- Brain Neoplasms
- COS Cells
- Cell Transformation, Neoplastic
- Cytoplasm
- Electrophoresis, Polyacrylamide Gel
- Humans
- In Vitro Techniques
- Ligands
- Mice
- Mice, Nude
- Mutation