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Article

A human brain tumor-derived PDGFR-alpha deletion mutant is transforming.

Oncogene - 6 Feb 2003

Clarke I D, Dirks P B

Abstract excerpt

Aberrant receptor tyrosine kinase signaling plays an important role in the molecular pathogenesis of brain tumors. We have been studying a previously identified human glioblastoma-derived PDGFR-alpha mutant that has an in-frame deletion in the extracellular domain, causing loss of exons 8 and 9 (PDGFR-alpha(delta8,9)). In the primary tumor, this deletion mutant receptor was shown to be amplified and...

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PMID: 12569364
DOI: 10.1038/sj.onc.1206160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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