Article
Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism.
International journal of cancer - 29 May 1996
Potapova O, Fakhrai H, Mercola D
Abstract excerpt
Numerous established human tumor lines co-express platelet-derived growth factor (PDGF) and cognate receptors, suggesting that an autocrine and/or paracrine growth mechanism may be a causal or contributing mechanism to their transformed phenotype. Indeed, it is known that a PDGF-autocrine system...
Topics
- Animals
- Antibodies, Neoplasm
- Antibody Specificity
- Breast Neoplasms
- Cell Division
- Cell Transformation, Neoplastic
- Female
- Glioblastoma
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phenotype
- Platelet-Derived Growth Factor
- Precipitin Tests