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Article

Unique microenvironmental responses to PDGF stimulation in brain and spinal cord gliomas determine tumor phenotype.

Journal of neuro-oncology - 1 May 2015

Ellis Jason A, Castelli Michael, Assanah Marcela, Bruce Jeffrey N, Canoll Peter, Ogden Alfred T

Abstract excerpt

Injection of a PDGF-B expressing retrovirus into the subcortical white matter of adult rats induces the rapid formation of brain tumors that have the histological features of glioblastoma. In contrast, when the same retrovirus is injected into the spinal cord of adult rats the resulting tumors are more indolent and display a unique histology characterized by nests of tumor cells separated by a dense vascular...

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Source

Identifiers

PMID: 25868602
DOI: 10.1007/s11060-015-1769-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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