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Article

PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.

Genes & development - 1 Oct 2010

Ozawa Tatsuya, Brennan Cameron W, Wang Lu, Squatrito Massimo, Sasayama Takashi, Nakada Mitsutoshi, Huse Jason T, Pedraza Alicia, Utsuki Satoshi, Yasui Yoshie, Tandon Adesh, Fomchenko Elena I, Oka Hidehiro, Levine Ross L, Fujii Kiyotaka, Ladanyi Marc, Holland Eric C

Abstract excerpt

Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas. However, the incidence of platelet-derived growth factor receptor-α (PDGFRA) gene rearrangement in these tumors is unknown. We investigated the PDGFRA locus in PDGFRA-amplified gliomas and identified two rearrangements, including the first case of...

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Identifiers

PMID: 20889717
DOI: 10.1101/gad.1972310
PMCID: PMC2947772

Genes

PDGFRA
EGFR
KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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