Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.

Cancer research - 15 Oct 2013

Paugh Barbara S, Zhu Xiaoyan, Qu Chunxu, Endersby Raelene, Diaz Alexander K, Zhang Junyuan, Bax Dorine A, Carvalho Diana, Reis Rui M, Onar-Thomas Arzu, Broniscer Alberto, Wetmore Cynthia, Zhang Jinghui, Jones Chris, Ellison David W, Baker Suzanne J

Abstract excerpt

The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor α (PDGFRA) is the most frequent target of focal amplification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Gene Expression Profiling

Share to Genome-Wide Association Study

Share to Glioma

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 23970477
DOI: 10.1158/0008-5472.CAN-13-1491
PMCID: PMC3800209

Genes

PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.PMID 23970477Read ↗

Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma.Semantic proximity Read ↗

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.Semantic proximity Read ↗

Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma.Semantic proximity Read ↗

PDGFRA in paediatric high-grade glioma - target or distraction?Semantic proximity Read ↗

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.Semantic proximity Read ↗

Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas.Semantic proximity Read ↗

Effective targeting of PDGFRA-altered high-grade glioma with avapritinib.Semantic proximity Read ↗

PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma.Semantic proximity Read ↗

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets.Semantic proximity Read ↗

Children are not just little adults: recent advances in understanding of diffuse intrinsic pontine glioma biology.Semantic proximity Read ↗

Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem gliomaSemantic proximity Read ↗

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.