Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line.

doi:10.1002/jcp.1041580221

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Article

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line.

Journal of cellular physiology - 1 Feb 1994

Vassbotn F S, Ostman A, Langeland N, Holmsen H, Westermark B, Heldin C H, Nistér M

Abstract excerpt

Human glioblastoma cells (A172) were found to concomitantly express PDGF-BB and PDGF beta-receptors. The receptors were constitutively autophosphorylated in the absence of exogenous ligand, suggesting the presence of an autocrine PDGF pathway. Neutralizing PDGF antibodies as well as suramin inhib...

Topics

Antibodies, Monoclonal
Cell Division
Cell Membrane
Cell Transformation, Neoplastic
DNA
Glioblastoma
Humans
Phenotype
Platelet-Derived Growth Factor
Precipitin Tests
Receptor Protein-Tyrosine Kinases
Receptors, Platelet-Derived Growth Factor
Tumor Cells, Cultured

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Open in PubMed

Identifiers

PMID: 8106574
DOI: 10.1002/jcp.1041580221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8106574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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