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Article

Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.

Science (New York, N.Y.) - 21 Feb 2003

Wedlich-Soldner Roland, Altschuler Steve, Wu Lani, Li Rong

Abstract excerpt

Cell polarization can occur in the absence of any spatial cues. To investigate the mechanism of spontaneous cell polarization, we used an assay in yeast where expression of an activated form of Cdc42, a Rho-type guanosine triphosphatase (GTPase) required for cell polarization, could generate cell polarity without any recourse to a preestablished physical cue. The polar distribution of Cdc42 in this assay required...

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Identifiers

PMID: 12560471
DOI: 10.1126/science.1080944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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