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Article

Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe.

PLoS biology - 1 Mar 2026

Saha Sajjita, Sajeevan Aiswarya, Merlini Laura, Vincenzetti Vincent, Martin Sophie G

Abstract excerpt

The conserved Cdc42 GTPase is a key driver of symmetry breaking and polarized growth, forming zones of activity that locally recruit effectors to organize the cytoskeleton and polarize secretion. Here, we show that Cdc42 also functions in cell-cell fusion during Schizosaccharomyces pombe sexual reproduction, but concentrates at the fusion site through mechanisms distinct from those proposed in Saccharomyces...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41855172
DOI: 10.1371/journal.pbio.3003712
PMCID: PMC13016475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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