Article
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995
Stowers L, Yelon D, Berg L J, Chant J
Abstract excerpt
The mechanisms by which cells rapidly polarize in the direction of external signals are not understood. Helper T cells, when contacted by an antigen-presenting cell, polarize their cytoskeletons toward the antigen-presenting cell within minutes. Here we show that, in T cells, the mammalian Ras-related GTPase CDC42 (the homologue of yeast CDC42, a protein involved in budding polarity) can regulate the polarization...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.