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Article

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.

Molecular biology of the cell - 1 Oct 2021

Pino Marbelys Rodriguez, Nuñez Illyce, Chen Chuan, Das Maitreyi E, Wiley David J, D'Urso Gennaro, Buchwald Peter, Vavylonis Dimitrios, Verde Fulvia

Abstract excerpt

The highly conserved small GTPase Cdc42 regulates polarized cell growth and morphogenesis from yeast to humans. We previously reported that Cdc42 activation exhibits oscillatory dynamics at cell tips of Schizosaccharomyces pombe cells. Mathematical modeling suggests that this dynamic behavior enables a variety of symmetric and asymmetric Cdc42 activation distributions to coexist in cell populations. For...

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PMID: 34288736
DOI: 10.1091/mbc.E20-10-0666
PMCID: PMC8684747

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