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Article

Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.

Nature communications - 1 Jan 2013

Freisinger Tina, Klünder Ben, Johnson Jared, Müller Nikola, Pichler Garwin, Beck Gisela, Costanzo Michael, Boone Charles, Cerione Richard A, Frey Erwin, Wedlich-Söldner Roland

Abstract excerpt

Establishment of cell polarity--or symmetry breaking--relies on local accumulation of polarity regulators. Although simple positive feedback is sufficient to drive symmetry breaking, it is highly sensitive to stochastic fluctuations typical for living cells. Here, by integrating mathematical modelling with quantitative experimental validations, we show that in the yeast Saccharomyces cerevisiae a combination of...

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Share to Bridged Bicyclo Compounds, Heterocyclic
Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Fluorescence Resonance Energy Transfer

Share to Guanine Nucleotide Dissociation Inhibitors

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Source

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Identifiers

PMID: 23651995
DOI: 10.1038/ncomms2795
PMCID: PMC3674238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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