Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth.

Science (New York, N.Y.) - 13 Jul 2012

Das Maitreyi, Drake Tyler, Wiley David J, Buchwald Peter, Vavylonis Dimitrios, Verde Fulvia

Abstract excerpt

Cells promote polarized growth by activation of Rho-family protein Cdc42 at the cell membrane. We combined experiments and modeling to study bipolar growth initiation in fission yeast. Concentrations of a fluorescent marker for active Cdc42, Cdc42 protein, Cdc42-activator Scd1, and scaffold protein Scd2 exhibited anticorrelated fluctuations and oscillations with a 5-minute average period at polarized cell tips....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Microscopy, Fluorescence

Share to p21-Activated Kinases

Share to Recombinant Fusion Proteins

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22604726
DOI: 10.1126/science.1218377
PMCID: PMC3681419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth.PMID 22604726Read ↗

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast.Semantic proximity Read ↗

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.Semantic proximity Read ↗

Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.Semantic proximity Read ↗

Cdc42 GTPase Activating Proteins (GAPs) Maintain Generational Inheritance of Cell Polarity and Cell Shape in Fission YeastSemantic proximity Read ↗

Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators.Semantic proximity Read ↗

Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase.Semantic proximity Read ↗

Shaping fission yeast with microtubules.Semantic proximity Read ↗

Distinct Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe.Semantic proximity Read ↗

Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling.Semantic proximity Read ↗

The shared role of the Rsr1 GTPase and Gic1/Gic2 in Cdc42 polarization.Semantic proximity Read ↗

Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.Semantic proximity Read ↗

Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.