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Article

Opposing roles for actin in Cdc42p polarization.

Molecular biology of the cell - 1 Mar 2005

Irazoqui Javier E, Howell Audrey S, Theesfeld Chandra L, Lew Daniel J

Abstract excerpt

In animal and fungal cells, the monomeric GTPase Cdc42p is a key regulator of cell polarity that itself exhibits a polarized distribution in asymmetric cells. Previous work showed that in budding yeast, Cdc42p polarization is unaffected by depolymerization of the actin cytoskeleton (Ayscough et al., J. Cell Biol. 137, 399-416, 1997). Surprisingly, we now report that unlike complete actin depolymerization, partial...

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Identifiers

PMID: 15616194
DOI: 10.1091/mbc.e04-05-0430
PMCID: PMC551493

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