Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity.

Nature cell biology - 19 Feb 2012

Das Arupratan, Slaughter Brian D, Unruh Jay R, Bradford William D, Alexander Richard, Rubinstein Boris, Li Rong

Abstract excerpt

Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis. Here we find that a lipid flippase complex, composed of Lem3, Dnf1 or Dnf2, has a role in the dynamic recycling of the Cdc42 GTPase, a key regulator of cell polarity, in yeast. By using quantitative microscopy methods, we show that the flippase complex is required for fast dissociation of Cdc42...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
Share to Fluorescence Recovery After Photobleaching

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Dissociation Inhibitors

Share to Membrane Lipids

Share to Multiprotein Complexes

Share to Phosphatidylethanolamines

Share to Phosphatidylserines

Share to Phospholipids

Source

Open in PubMed Open full text

Identifiers

PMID: 22344035
DOI: 10.1038/ncb2444
PMCID: PMC3534761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity.PMID 22344035Read ↗

Transbilayer phospholipid flipping regulates Cdc42p signaling during polarized cell growth via Rga GTPase-activating proteins.Semantic proximity Read ↗

Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.Semantic proximity Read ↗

Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry.Semantic proximity Read ↗

Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling.Semantic proximity Read ↗

Exo-endocytic trafficking and the septin-based diffusion barrier are required for the maintenance of Cdc42p polarization during budding yeast asymmetric growth.Semantic proximity Read ↗

Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane.Semantic proximity Read ↗

Opposing roles for actin in Cdc42p polarization.Semantic proximity Read ↗

Isolation and characterization of novel mutations in CDC50, the non-catalytic subunit of the Drs2p phospholipid flippase.Semantic proximity Read ↗

Crystal structure of a human plasma membrane phospholipid flippaseSemantic proximity Read ↗

Aspergillus nidulans flippase DnfA is cargo of the endocytic collar and plays complementary roles in growth and phosphatidylserine asymmetry with another flippase, DnfB.Semantic proximity Read ↗

Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast.Semantic proximity Read ↗

The putative aminophospholipid translocases, DNF1 and DNF2, are not required for 7-nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine flip across the plasma membrane of Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.